Kayastha Pathshala has produced many notable alumni, including Mahamana Madan Mohan Malviya, Rajarshi Purushottam Das Tandon, Ganesh Shankar Vidyarthi, former President Dr. Shankar Dayal Sharma, former Chief Minister Hemwati Nandan Bahuguna, Maharishi Mahesh Yogi, Babu Mangala Prasad, and Acharya Ram Chandra Shukla.
Several teachers from Kayastha Pathshala’s educational institutions were honored with the President's Award, such as Mr. M.G. Gaud, Mr. Maharaj Bahadur Srivastava, Mr. G.C. Saxena, Mr. R.S. Mathur, and Mr. Chandramohan.
Prominent principals of the institution include Mr. Ramanand Chatterjee, Mr. F.G. Priyadarshan, Mr. Gokul Chand, Mr. J. Sen, Mr. Madhav Prasad, Mr. Jalpa Prasad, Mr. G.P. Srivastava, and Dr. Tarachand, who also served as the Vice Chancellor of Allahabad University and the Ambassador to Russia.
The institution’s distinguished teachers, including Hindi literature critic Mr. Balkrishna Bhatt, Mr. Satyajeevan Verma, Prof. Gaya Prasad, Mr. G.N. Verma, Mr. Devendra Singh, Mr. Ganpat Verma, Mr. Vidyanand, and Mr. N.C. Mukherjee, significantly elevated the prestige of Kayastha Pathshala.