Kayastha Pathshala has been the alma mater of many distinguished individuals, including Mahamana Madan Mohan Malaviya, Rajarshi Purushottam Das Tandon, Ganesh Shankar Vidyarthi, former President Dr. Shankar Dayal Sharma, former Chief Minister Hemwati Nandan Bahuguna, Maharishi Mahesh Yogi, Babu Mangala Prasad, and Acharya Ram Chandra Shukla.
Several teachers from Kayastha Pathshala's institutions have been honored with the President's Award, such as Mr. M.G. Gaur, Mr. Maharaj Bahadur Srivastava, Mr. G.C. Saxena, Mr. R.S. Mathur, and Mr. Chandramohan.
The institution has also been guided by prominent principals, including Mr. Ramanand Chatterjee, Mr. F.G. Priyadarshan, Mr. Gokul Chand, Mr. J. Sen, Mr. Madhav Prasad, Mr. Jalpa Prasad, Mr. G.P. Srivastava, and Dr. Tarachand, who later served as the Vice-Chancellor of Allahabad University and the Ambassador to Russia.
Distinguished teachers like Hindi literature critic Mr. Balkrishna Bhatt, Mr. Satyajeevan Verma, Prof. Gaya Prasad, Mr. G.N. Verma, Mr. Devendra Singh, Mr. Ganpat Verma, Mr. Vidyanand, and Mr. N.C. Mukherjee have played a pivotal role in enhancing the prestige of Kayastha Pathshala.